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St John's Wort Remedies

St John's Wort - Herbal Research
A WHO Organizational resource: St John's Wort Research - FULL REPORT

Medicinal uses supported by clinical data
Symptomatic treatment of mild and moderate depressive episodes (classified as F32.0 and F32.1, respectively, in the International statistical classification of diseases and related health problems, Tenth revision (ICD-10) (18)) (19-31).
Uses reported in pharmacopoeias and in traditional systems of medicine
Externally for the treatment of minor cuts, burns and skin ulcers (8, 32). Topically for viral infections (33).
Uses described in folk medicine, not supported by experimental or clinical data
As an antiphlogistic agent in the treatment of inflammation of the bronchi and urogenital tract; treatment of biliary disorders, bladder irritation, the common cold, diabetes mellitus, dyspepsia, haemorrhoids, neuralgia, migraine headaches, sciatica and ulcers (5, 8). Also used as a diuretic, an emmenagogue and an antimalarial agent (5, 8).
5. Farnsworth NR, ed. NAPRALERT database. Chicago, University of Illinois at Chicago, IL, February 9, 1998 production (an online database available directly through the University of Illinois at Chicago or through the Scientific and Technical Network [STN] of Chemical Abstracts Services).
8. Bombardelli E, Morazzoni P. Hypericum perforatum. Fitoterapia, 1995, 66:43-68.
18. International statistical classification of diseases and related health problems, Tenth revision (ICD-10), Volume 1. Geneva, World Health Organization, 1992.
19. Ernst E. St John’s wort, an antidepressant? A systematic, criteria-based review. Phytomedicine, 1995, 2:67-71.
20. Laakmann G et al. St John’s wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy. Pharmacopsychiatry, 1998, 31 (Suppl. 1):S54-S59.
21. Linde K et al. St John’s wort for depression - an overview and meta-analysis of randomized clinical trials. British Medical Journal, 1996, 313:253-258.
22. Maisenbacher HJ et al. Therapie von Depressionen in der Praxis. Ergebnisse einer Anwendungsbeobachtung mit Hyperici herba. Natura Medica, 1992, 7:394-399.
23. Pieschl D et al. Zur Behandlung von Depressionen. Verblindstudie mit einem pflanzlichen Extrakt Johanniskraut. Therapiewoche, 1989, 39:2567-2571.
24. Schrader E et al. Hypericum treatment of mild-moderate depression in a placebocontrolled study. A prospective, double-blind, randomized, placebo-controlled, multicentre study. Human Psychopharmacology, 1998, 13:163-169.
25. Schultz H, Jobert M. Effects of Hypericum extract on the sleep EEG in older volunteers. Journal of Geriatric Psychiatry and Neurology, 1994, 7 (Suppl. 1):S39-S43.
26. Schultz H et al. Clinical trials with phyto-psychopharmacological agents. Phytomedicine, 1997, 4:379-387.
27. Volz HP. Controlled clinical trials of Hypericum extracts in depressed patients - an overview. Pharmacopsychiatry, 1997, 30:72-76.
28. Vorbach EU, Arnoldt KH, Hübner W-D. Efficacy and tolerability of St John’s wort extract LI 160 versus imipramine in patients with severe depressive episodes according to ICD-10. Pharmacopsychiatry, 1997, 30:81-85.
29. Wheatley D. LI 160, an extract of St John’s wort, versus amitriptyline in mildly to moderately depressed outpatients - a controlled 6-week clinical trial. Pharmacopsychiatry, 1997, 30:77-80.
30. Wheatley D. Hypericum extract: potential in the treatment of depression. CNS Drugs, 1998, 9:431-440.
31. Woelk H et al. Benefits and risks of the Hypericum extract LI 160: drugmonitoring study with 3250 patients. Journal of Geriatric Psychiatry and Neurology, 1994, 7 (Suppl. 1):S34-S38.
32. Blumenthal M et al., eds. The complete German Commission E monographs. Austin, TX, American Botanical Council, 1998.
33. Ivan H. Preliminary investigations on the application of Hypericum perforatum in herpes therapy. Gyogyszereszet, 1979, 23:217-218.

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