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Barberry - Herbal Research:
A WHO Organizational resource: Barberry Research - FULL REPORT

Medicinal uses supported by clinical data
Uses described in pharmacopoeias and well established documents
Used orally for the treatment of digestive complaints, such as dyspepsia, diarrhoea, gastritis, feelings of distention and flatulence (1).
Although  no  clinical  trials  evaluating  Cortex  Berberidis  have  been  conducted,  the  most  relevant  active  principle  is  known  to  be  berberine.  Berberine has been shown to be effective for the treatment of bacterially-induced diarrhoea (14–20), ocular trachoma (21) and cutaneous leishmaniasis (22–25).
Uses described in traditional medicine
Used orally for the treatment of cystitis, dysmenorrhoea, eczema, fever, haemorrhoids,  inflammation,  menorrhagia,  nasal  congestion,  rheumatism, tinnitus and vaginitis (4,26,27). Also used as a cholagogue, diuretic, emmenagogue, haemostat, laxative and a tonic (4).


1. British herbal pharmacopoeia, Vol. 1. Exeter, British Herbal Medicine Association, 1996
4.Farnsworth NR, ed.NAPRALERT database. Chicago, University of Illinois at Chicago, IL (an online database available directly through the University of Illinois at Chicago or through the Scientific and Technical Network [STN]of Chemical Abstracts Services), 30 June 2005
14. Khin-Maung U et al. Clinical trial of berberine in acute watery diarrhoea. British Medical Journal,  1986, 291:1601–1605.
15. Lahiri  SC,  Dutta  NK.  Berberine  and  chloramphenicol  in  the  treatment  of cholera and severe diarrhoea. Journal of the Indian Medical Association, 1967, 48:1–11.
16. Chauhan RK, Jain AM, Bhandari B. Berberine in the treatment of childhood diarrhoea. Indian Journal of Pediatrics, 1970, 37:577–579.
17. Rabbani GH et al. Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae. Journal of Infectious Diseases, 1987, 155:979–984.
18. Sharda  DC.  Berberine  in  the  treatment  of  diarrhoea  in  infancy  and  childhood. Journal of the Indian Medical Association, 1970, 54:22–24.
19. Sharma R, Joshi CK, Goyal RK. Berberine tannate in acute diarrhoea. Indian Journal of Pediatrics, 1970, 7:496–501.
20. Tang W, Eisenbrand G. Chinese drugs of plant origin. London, Springer-Ver-lag, 1992.
21. Mohan  M  et  al.  Berberine  in  trachoma. Indian  Journal  of  Ophthalmology,1982, 30:69–75.
22. Das  Gupta  BM.  The  treatment  of  oriental  sore  with  berberine  acid  sulfate. Indian Medical Gazette, 1930, 65:683–685.
23. Das Gupta BM, Dikshit BB. Berberine in the treatment of Oriental boil. Indian Medical Gazette, 1929, 67:70.
24. Devi  AL.  Berberine  sulfate  in  oriental  sore. Indian  Medical  Gazette, 1929, 64:139.
25. Peirce  A. The  APhA  practical  guide  to  natural  medicines.  New  York,  NY, Stonesong Press, Wm. Morrow & Co., 1999.
26. Kupeli E et al. A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species. Life Sciences, 2002, 72:645–657.
27. Zolotnitskaya  SY,  ed. Pharmaceutical  resources  of  Armenian  Flora,  Vol.  2. Yerevan, Armenia, SSR AN Publishers, 1965

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