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Research

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Milk Thistle


Milk Thistle - Herbal Research

Medicinal uses supported by clinical data
 
Supportive treatment of acute or chronic hepatitis and cirrhosis induced by alcohol, drugs or toxins (21-34).
 
Uses described in pharmacopoeias and in traditional systems of medicine
 
Treatment of dyspeptic complaints and gallstones (7, 35).
 
Uses described in folk medicine, not supported by experimental or clinical data
 
Treatment of amenorrhoea, constipation, diabetes, hay fever, uterine haemorrhages and varicose veins (6).

References:
6. Farnsworth NR, ed. NAPRALERT database. Chicago, University of Illinois at Chicago, IL, February 9, 1998 production (an online database available directly through the University of Illinois at Chicago or through the Scientific and Technical Network [STN] of Chemical Abstracts Services).
 
7. Morazzoni P, Bombardelli E. Silybum marianum (Carduus marianus). Fitoterapia, 1995, 66:3-42.
 
21. Albrecht M et al. Die Therapie toxischer Leberschäden mit Legalon®. Zeitschrift für Klinische Medizin, 1992, 47:87-92.
 
22. Berenguer J, Carrasco D. Ensayo doble ciego de Silimarina frente a placebo en el tratamiento de hepatopatías crónicas de diversa génesis. Münchener Medizinische Wochenschrift, 1977, 119:240-260.
 
23. Deák G et al. Silymarin kezelés immunmoduláns hatása krónikus alkoholos májbetegségben. Orvosi Hetilap, 1990, 131:1291-1296.
 
24. Feher J, Lang I. Wirkmechanismen der sogenannten Leberschutzmittel. Bayer Internist, 1988, 4:3-7.
 
25. Feher J et al. Hepatoprotective activity of silymarin Legalon therapy in patients with chronic alcoholic liver disease. Orvosi Hetilap, 1989, 130:2723-2727.
 
26. Ferenci P et al. Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. Journal of Hepatology, 1989, 9:105-113.
 
27. Fintelmann V, Albert A. Nachweis der therapeutischen Wirksamkeit von Legalon® bei toxischen Lebererkrankungen im Doppelblindversuch. Therapiewoche, 1980, 30:5589-5594.
 
28. Grüngreiff K et al. Nutzen der medikamentösen Lebertherapie in der hausärztlichen Praxis. Die Medizinische Welt, 1995, 46:222-227.
 
29. Müzes M et al. Silymarin (Legalon®) kezelés hatása idült alkoholos májbetegek antioxidáns védorendszerée és a lipid peroxidációra (kettos vak protokoll). Orvosi Hetilap, 1990, 131:863-866.
 
30. Láng I et al. Hepatoprotective and immunomodulatory effects of antioxidant therapy. Acta Medica Hungarica, 1988, 45:287-295.
 
31. Salmi HA, Sarna S. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Scandinavian Journal of Gastroenterology, 1982, 17:517-521.
 
32. Szilárd S et al. Protective effect of Legalon® in workers exposed to organic solvents. Acta Medica Hungarica, 1988, 45:249-256.
 
33. Varis K et al. Die Therapie der Lebererkrankung mit Legalon: eine kontrollierte Doppelblindstudie. In: Aktuelle Hepathologie, Third International Symposium, Cologne. Lübeck, Hanseatisches Verlagskontor, 1978:42-43.
 
34. Vogel G. Natural substances with effects on the liver. In: Wagner H, Wolff P. New natural products and plant drugs with pharmacological, biological or therapeutic activity. New York, NY, Springer-Verlag, 1977:2651-2665.
 
35. Blumenthal M et al., eds. The complete German Commission E monographs. Austin, TX, American Botanical Council, 1998.


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