Guggul - Herbal Research:
A WHO Organizational resource: Guggul - FULL REPORT
Medicinal uses supported by clinical data
Treatment of hyperlipidaemia and hypercholesterolaemia (1, 26–33). Clinical investigations to assess the use of extracts of the oleo-gum resin for the treatment of obesity were negative (34, 35) (see Clinical pharmacology).
Uses described in pharmacopoeias and well established documents
Treatment of atherosclerosis, rheumatic conditions, cough, sore throat and menopausal symptoms. As an emmenagogue (3, 4, 8, 9, 16).
Uses described in traditional medicine
Internally as an expectorant and for treatment of diarrhoea, fatigue, headache, jaundice and indigestion; topically for treatment of burns (12, 16, 36–38). Also as an insecticide and insect repellent (9)
References:
1. Studies on gugglu. New Delhi, Central Council for Research in Ayurveda and Siddha, Ministry of Health and Family Welfare, 1989.
3. The Ayurvedic pharmacopoeia of India. Part I. Vol. I. New Delhi, Ministry of Health and Family Welfare, Department of Indian System of Medicine and Homeopathy, 1999.
4. Unani pharmacopoeia of India. Part 1. Vol. 1. New Delhi, Ministry of Health and Family Welfare, Department of India Systems of Medicine and Homeopathy, 1999
8. Medicinal plants of India. Vol. 1. New Delhi, Indian Council of Medical Research, 1987.
9. Pandy VN, Malhotra SC, eds. Pharmacological and clinical studies on gugulu (Commiphora wightii) in hyperlipidaemia and lipid metabolism. New Delhi, Central Council for Research in Ayurveda and Siddha, Ministry of Health and Family Welfare, 1992.
12. Farnsworth NR, ed. NAPRALERT database. Chicago, IL, University of Illinois at Chicago, 10 January 2001 production (an online database available directly through the University of Illinois at Chicago or through the Scien-
tific and Technical Network (STN) of Chemical Abstracts Services).
16. Mitra AP et al., eds. The wealth of India: A dictionary of Indian raw materials and industrial products: Raw materials, Vol. 2:B. New Delhi, Council of Scientific and Industrial Research, 1948
26. Malhotra SC, Ahuja MMS. Comparative hypolipidaemic effectiveness of gum guggulu (Commiphora mukul)
fraction ‘A’, ethyl-p-chlorophenoxyiso-butyrate and Ciba-13437-Su. Indian Journal of Medical Research, 1971,
59:1621–1632.
27. Kuppurajan K et al. Effect of guggulu (Commiphora mukul-Engl.) on serum lipids in obese subjects. Journal of Research in Indian Medicine, 1973, 8:1–8.
28. Malhotra SC, Ahuja MMS, Sundaram KR. Long term clinical studies on the hypolipidaemic effect of Commiphora mukul (guggulu) and clofibrate. Indian Journal of Medical Research, 1977, 65:390–395.
29. Kuppurajan K et al. Effect of guggulu (Commiphora mukul-Engl.) on serum lipids in obese, hypercholesterolemic and hyperlipemic cases. Journal of the Association of Physicians of India, 1978, 26:367–373.
30. Agarwal RC et al. Clinical trial of gugulipid, a new hypolipidemic agent of plant origin in primary hyperlipidemia.
Indian Journal of Medical Research, 1986, 84:626–634.
31. Satyavati GV. Gum guggul (Commiphora mukul) – the success story of an ancient insight leading to a modern discovery. Indian Journal of Medical Research, 1988, 87:327–335.
32. Verma SK, Bordia A. Effect of Commiphora mukul (gum guggulu) in patients of hyperlipidemia with special reference to HDL-cholesterol. Indian Journal of Medical Research, 1988, 87:356–360.
33. Singh RB, Niaz MA, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hyper-cholesterolemia. Cardiovascular Drugs and Therapy, 1994, 8:659–664.
34. Kotiyal JP, Singh DS, Bisht DB. Study of hypolipidaemic effect of Commiphora mukul (gum guggulu) fraction “A” in obesity. Journal of Research in Ayurveda and Siddha, 1980, 1:335–344.
35. Kotiyal JP, Singh DS, Bisht DD. Gum guggulu (Commiphora mukul) fraction “A” in obesity – a double-blind clinical trial. Journal of Research in Ayurveda and Siddha, 1984, 6:20–35.
36. Nadkarni KM. Indian materia medica. Bombay, Popular Prakashan, 1976.
37. Frawley D, Lad V. The yoga of herbs: an Ayurvedic guide to herbal medicine. Twin Lakes, WI, Lotus Press, 1986.
38. Iwu MM. Handbook of African medicinal plants. Boca Raton, FL, CRC Press, 1993
