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Guggul


Guggul - Herbal Research:
A WHO Organizational resource: Guggul - FULL REPORT


Medicinal uses supported by clinical data
Treatment  of  hyperlipidaemia  and  hypercholesterolaemia  (1,  26–33). Clinical  investigations  to  assess  the  use  of  extracts  of  the  oleo-gum resin  for  the  treatment  of  obesity  were  negative  (34,  35)  (see  Clinical pharmacology).
 
Uses described in pharmacopoeias and well established documents
Treatment  of  atherosclerosis,  rheumatic  conditions,  cough,  sore  throat and menopausal symptoms. As an emmenagogue (3, 4, 8, 9, 16).
 
Uses described in traditional medicine
Internally as an expectorant and for treatment of diarrhoea, fatigue, headache,  jaundice  and  indigestion;  topically  for  treatment  of  burns  (12,  16,  36–38). Also as an insecticide and insect repellent (9)  

References:

 
1. Studies  on  gugglu. New  Delhi,  Central  Council  for  Research  in  Ayurveda and Siddha, Ministry of Health and Family Welfare, 1989.
 
3. The Ayurvedic pharmacopoeia of India. Part I. Vol. I. New Delhi, Ministry of  Health  and  Family  Welfare,  Department  of  Indian  System  of  Medicine and Homeopathy, 1999. 
 
4. Unani pharmacopoeia of India. Part 1. Vol. 1. New Delhi, Ministry of Health and  Family  Welfare,  Department  of  India  Systems  of  Medicine  and  Homeopathy, 1999
 
8. Medicinal plants of India. Vol. 1. New Delhi, Indian Council of Medical Research, 1987. 
 
9. Pandy VN, Malhotra SC, eds. Pharmacological and clinical studies on gugulu (Commiphora wightiiin hyperlipidaemia and lipid metabolism. New Delhi, Central  Council  for  Research  in  Ayurveda  and  Siddha,  Ministry  of  Health and Family Welfare, 1992. 
 
12.  Farnsworth  NR,  ed. NAPRALERT  databaseChicago,  IL,  University  of  Illinois at Chicago, 10 January 2001 production (an online database available directly through the University of Illinois at Chicago or through the Scien-
tific and Technical Network (STN) of Chemical Abstracts Services).
 
16.  Mitra AP et al., eds. The wealth of India: A dictionary of Indian raw materials and industrial products: Raw materials, Vol. 2:B. New Delhi, Council of Scientific and Industrial Research, 1948
 
26.  Malhotra  SC,  Ahuja  MMS.  Comparative  hypolipidaemic  effectiveness  of gum guggulu (Commiphora mukul)
 fraction ‘A’, ethyl-p-chlorophenoxyiso-butyrate  and  Ciba-13437-Su. Indian Journal  of  Medical  Research 1971,  
59:1621–1632.
 
27. Kuppurajan K et al. Effect of guggulu (Commiphora mukul-Engl.) on serum lipids in obese subjects. Journal of Research in Indian Medicine, 1973, 8:1–8.
 
28. Malhotra SC, Ahuja MMS, Sundaram KR. Long term clinical studies on the hypolipidaemic  effect  of  Commiphora  mukul (guggulu)  and  clofibrate. Indian Journal of Medical Research, 1977, 65:390–395.
 
29. Kuppurajan K et al. Effect of guggulu (Commiphora mukul-Engl.) on serum lipids in obese, hypercholesterolemic and hyperlipemic cases. Journal of the Association of Physicians of India, 1978, 26:367–373.
 
30. Agarwal RC et al. Clinical trial of gugulipid, a new hypolipidemic agent of plant origin in primary hyperlipidemia. 
Indian Journal of Medical Research1986, 84:626–634.
 
31. Satyavati  GV.  Gum  guggul  (Commiphora  mukul)  –  the  success  story  of  an ancient insight leading to a modern discovery. Indian Journal of Medical Research, 1988, 87:327–335.
 
32. Verma  SK,  Bordia  A.  Effect  of  Commiphora  mukul (gum  guggulu)  in  patients of hyperlipidemia with special reference to HDL-cholesterol. Indian Journal of Medical Research, 1988, 87:356–360.
 
33. Singh  RB,  Niaz  MA,  Ghosh  S.  Hypolipidemic  and  antioxidant  effects  of Commiphora mukul  as an adjunct to dietary therapy in patients with hyper-cholesterolemia. Cardiovascular Drugs and Therapy, 1994, 8:659–664.
 
34.  Kotiyal  JP,  Singh  DS,  Bisht  DB.  Study  of  hypolipidaemic  effect  of Commiphora mukul  (gum guggulu) fraction “A” in obesity. Journal of Research in Ayurveda and Siddha, 1980, 1:335–344.
 
35.  Kotiyal JP, Singh DS, Bisht DD. Gum guggulu (Commiphora mukul) fraction  “A”  in  obesity  –  a  double-blind  clinical  trial.  Journal  of  Research  in Ayurveda and Siddha, 1984, 6:20–35.
 
36.  Nadkarni  KM. Indian materia medica. Bombay, Popular Prakashan, 1976.
 
37.  Frawley D, Lad V. The yoga of herbs: an Ayurvedic guide to herbal medicineTwin Lakes, WI, Lotus Press, 1986. 
 
38.  Iwu  MM. Handbook  of  African  medicinal  plants Boca  Raton,  FL,  CRC Press, 1993


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