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Artichoke - Herbal Research
A WHO Organizational resource: Artichoke Research - FULL REPORT

Medicinal uses supported by clinical data
Treatment of digestive complaints (e.g. dyspepsia, feeling of fullness, flatulence,  nausea,  stomach  ache  and  vomiting)  (15,22,23).  Adjunct  treatment of mild to moderate hypercholesterolaemia (22,24–27).
Uses described in pharmacopoeias and well established documents
Orally for the treatment of atherosclerosis and kidney dysfunctions (diuretic) (5).
One study has indicated that the crude drug may be of benefit for the treatment of irritable bowel syndrome (28), but further randomized controlled clinical trials are needed before any therapeutic recommendations can be made.
Uses described in traditional medicine
Oral treatment of anaemia, diabetes, fever, gout, rheumatism and urinary stones (7,9,29)

5. African pharmacopoeiaVol. 1, 1st ed. Lagos, Nigeria, Organization of African Unity, Scientific Technical & Research Commission, 1985.
7. Farnsworth NR, NAPRALERT databaseChicago, University of Illinois at Chicago, IL (an online database available directly through the University of Illinois at Chicago or through the Scientific and Technical Network [STN] of Chemical Abstracts Services), 30 June 2005.
9. Mills S, Bone K. Principles and practice of phytotherapy. Edinburgh, Churchill Livingstone, 2000.
15. Blumenthal M, Goldberg A, Brinckmann J, eds. Herbal medicine: expanded Commission E monographs. Austin, TX, American Botanical Council, 2000.
22. Kraft K. Artichoke leaf extract – Recent findings reflecting effects on lipid metabolism, liver and gastrointestinal effects. Phytomedicine, 1997, 4:369–378.
23. Kirchhoff R et al. Increase in choleresis by means of artichoke extract. Phytomedicine, 1994, 1:107–115.
24. Englisch W et al. Efficacy of artichoke dry extract in patients with hyperlipo-proteinemia. Arzneimittel-Forschung,
2000, 50:260–265.
25. Fintelmann  V.  Antidyspeptische  und  lipidsenkende  Wirkungen  von  Artischockenblätterextrakt.  Ergebnisse  klinischer  Untersuchungen  zur  Wirksamkeit und Verträglichkeit von Hepar-SL® forte an 553 Patienten. Zeitschrift
für Allgemeinmedizin, 1996, 72(Suppl 2):3–19 [in German].
26. Fintelmann  V,  Petrowicz  O.  Langzeitanwendung  eines  Artischocken-Ex-tracktes  bei  dyspeptischem  Symptomkomplex.  Naturamed, 1998,  13:17–26  [in German].
27. Petrowicz O et al. Effects of artichoke leaf extract (ALE) on lipoprotein metabolism in vitro and in vivo. 
Atherosclerosis, 1997, 129:147.
28. Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms  of  irritable  bowel  syndrome  in  a  post-marketing  surveillance  study. Phytotherapy Research, 2001, 15:58–61.
29. Wegener  T,  Fintelmann  V.  Pharmakologische  Eigenschaften  und  therapeutisches  Profil  der  Artischocke  (Cynara  scolymus  L.).  Wiener  medizinische Wochenschrift, 1999, 149:241–247 [in German]

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